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Phospho FoxO1 (S256) Cell-Based Colorimetric ELISA Kit

商品貨號： PLA000085

適應(yīng) 性： 人,小鼠,大鼠

￥2400元

規(guī)格：

96T

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MSDS

說明書

商品描述

發(fā)貨日期： 14
基因名稱： FOXO1
Human_gene_id： 2308
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2308
Human_swiss_prot_no： Q12778
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q12778/entry
Mouse_swiss_prot_no： Q9R1E0
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9R1E0
Rat_swiss_prot_no： G3V7R4
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941G3V7R4
儲存： 2-8°C/6 months
說明書： KA1083C.pdf
其他名稱： Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)
功能： blood vessel development,?vasculature development,?transcription,?regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter,?anti-apoptosis,?cell surface receptor linked signal transduction,?enzyme linked receptor protein signaling pathway,?transmembrane receptor protein tyrosine kinase signaling pathway,?insulin receptor signaling pathway,?response to endogenous stimulus,?response to hormone stimulus,?positive regulation of biosynthetic process,?response to organic substance,?positive regulation of macromolecule biosynthetic process,?positive regulation of macromolecule metabolic process,?positive regulation of gene expression,?regulation of cell death,?positive regulation of cellular biosynthetic process,?response to insulin stimulus,?cellular response to insulin stimulus,?cellular response to hormone stimulus,?regulation of cell proliferation,regulation of apoptosis,?negative regulation of apoptosis,?regulation of programmed cell death,?negative regulation of programmed cell death,?response to peptide hormone stimulus,?regulation of transcription,?positive regulation of transcription, DNA-dependent,?positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,?positive regulation of transcription,?positive regulation of transcription from RNA polymerase II promoter,positive regulation of nitrogen compound metabolic process,?regulation of RNA metabolic process,?positive regulation of RNA metabolic process,?negative regulation of cell death,
相關(guān)產(chǎn)品： YT1761,YT1758,YT1757,YP0652,YP0114,YP0113,KA4382C,KA3108C,KA1575C,KA1285C,KA1083C
細(xì)胞定位： Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells (PubMed:11311120, PubMed:12228231, PubMed:19221179, PubMed:21245099, PubMed:20543840, PubMed:25009184). In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway (PubMed:11237865, PubMed:12228231). Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation (PubMed:18356527). Phosphorylation by NLK results in nuclear export (By similarity). Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1 (PubMed:19221179, PubMed:21245099). SGK1-mediated phosphorylation also results in nuclear translocation (By similarity). Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide (By similarity). Retained in the nucleus on methylation (By similarity). PPIA/CYPA stimulates its nuclear accumulation (PubMed:31063815). Deacetylation by SIRT6, promotes its translocation into the cytoplasm (PubMed:25009184). .
組織表達(dá)： Ubiquitous.
科研貨號： PLA000085

Phospho FoxO1 (S256) Cell-Based Colorimetric ELISA Kit

Catalog No PLA000085

Product information

發(fā)貨日期： 14
基因名稱： FOXO1
Human_gene_id： 2308
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2308
Human_swiss_prot_no： Q12778
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q12778/entry
Mouse_swiss_prot_no： Q9R1E0
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9R1E0
Rat_swiss_prot_no： G3V7R4
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941G3V7R4
儲存： 2-8°C/6 months
說明書： KA1083C.pdf
其他名稱： Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)
功能： blood vessel development,?vasculature development,?transcription,?regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter,?anti-apoptosis,?cell surface receptor linked signal transduction,?enzyme linked receptor protein signaling pathway,?transmembrane receptor protein tyrosine kinase signaling pathway,?insulin receptor signaling pathway,?response to endogenous stimulus,?response to hormone stimulus,?positive regulation of biosynthetic process,?response to organic substance,?positive regulation of macromolecule biosynthetic process,?positive regulation of macromolecule metabolic process,?positive regulation of gene expression,?regulation of cell death,?positive regulation of cellular biosynthetic process,?response to insulin stimulus,?cellular response to insulin stimulus,?cellular response to hormone stimulus,?regulation of cell proliferation,regulation of apoptosis,?negative regulation of apoptosis,?regulation of programmed cell death,?negative regulation of programmed cell death,?response to peptide hormone stimulus,?regulation of transcription,?positive regulation of transcription, DNA-dependent,?positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,?positive regulation of transcription,?positive regulation of transcription from RNA polymerase II promoter,positive regulation of nitrogen compound metabolic process,?regulation of RNA metabolic process,?positive regulation of RNA metabolic process,?negative regulation of cell death,
相關(guān)產(chǎn)品： YT1761,YT1758,YT1757,YP0652,YP0114,YP0113,KA4382C,KA3108C,KA1575C,KA1285C,KA1083C
細(xì)胞定位： Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells (PubMed:11311120, PubMed:12228231, PubMed:19221179, PubMed:21245099, PubMed:20543840, PubMed:25009184). In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway (PubMed:11237865, PubMed:12228231). Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation (PubMed:18356527). Phosphorylation by NLK results in nuclear export (By similarity). Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1 (PubMed:19221179, PubMed:21245099). SGK1-mediated phosphorylation also results in nuclear translocation (By similarity). Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide (By similarity). Retained in the nucleus on methylation (By similarity). PPIA/CYPA stimulates its nuclear accumulation (PubMed:31063815). Deacetylation by SIRT6, promotes its translocation into the cytoplasm (PubMed:25009184). .
組織表達(dá)： Ubiquitous.
科研貨號： PLA000085

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