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Phospho Integrin β1 (T789) Cell-Based Colorimetric ELISA Kit

商品貨號： PLA000290

適應性： 人,小鼠,大鼠

￥2400元

規(guī)格：

96T

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MSDS

說明書

商品描述

發(fā)貨日期： 14
基因名稱： ITGB1
Human_gene_id： 3688
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3688
Human_swiss_prot_no： P05556
Human_swiss_link： http://www.uniprot.org/uniprotkb/P05556/entry
Mouse_swiss_prot_no： P09055
Mouse_swiss_link： http://www.uniprot.org/uniprot/P09055
Rat_swiss_prot_no： P49134
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P49134
儲存： 2-8°C/6 months
說明書： KA1288C.pdf
其他名稱： Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29)
功能： G1/S transition of mitotic cell cycle,?mitotic cell cycle,?in utero embryonic development,?cell fate specification,?cell activation,?immune system development,?leukocyte differentiation,?cell motion,?defense response,?cellular defense response,?cytoskeleton organization,?cell cycle,?cell adhesion,?homophilic cell adhesion,?leukocyte adhesion,?cell-matrix adhesion,?cell surface receptor linked signal transduction,?integrin-mediated signaling pathway,?gamete generation,heart development,?muscle organ development,?positive regulation of cell proliferation,?germ cell migration,?embryonic development ending in birth or egg hatching,?cellular component assembly involved in morphogenesis,?striated muscle tissue development,?cell-cell adhesion,?cell migration,?sexual reproduction,?cell cycle process,?cell cycle phase,biological adhesion,?actin filament-based process,?actin cytoskeleton organization,?hemopoiesis,?lymphocyte differentiation,?B cell differentiation,?myofibril assembly,?actomyosin structure organization,?cell-substrate adhesion,multicellular organism reproduction,?cellular component morphogenesis,?cell adhesion mediated by integrin,?cell-cell adhesion mediated by integrin,?cardiac cell differentiation,?B cell activation,?regulation of cell proliferation,?muscle cell differentiation,?chordate embryonic development,?cell fate commitment,?sarcomere organization,?leukocyte activation,negative regulation of cell differentiation,?lymphocyte activation,?hemopoietic or lymphoid organ development,reproductive process in a multicellular organism,?reproductive cellular process,?cardiac muscle tissue development,?cell motility,?striated muscle cell differentiation,?interphase,?interphase of mitotic cell cycle,?localization of cell,?regulation of cell cycle,?muscle cell development,?striated muscle cell development,?cardiac muscle cell differentiation,?muscle tissue development,
相關產品： YT5583,YT2368,YT2367,YT2366,YP0879,YP0496,YP0143,KA4139C,KA1773C,KA1288C,KA1262C
細胞定位： Cell membrane ; Single-pass type I membrane protein . Cell projection, invadopodium membrane ; Single-pass type I membrane protein . Cell projection, ruffle membrane ; Single-pass type I membrane protein . Recycling endosome . Melanosome . Cleavage furrow . Cell projection, lamellipodium . Cell projection, ruffle . Cell junction, focal adhesion . Cell surface . Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. .; [Isoform 5]: Cell membrane, sarcolemma . Cell junction . In cardiac muscle, isoform 5 is found in costameres and intercalated disks. .
組織表達： [Isoform 1]: Widely expressed, other isoforms are generally coexpressed with a more restricted distribution. ; [Isoform 2]: Expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. ; [Isoform 3]: Together with isoform 4, is expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. ; [Isoform 4]: Together with isoform 3, is expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Rather than isoform 3, is selectively expressed in peripheral T-cells. ; [Isoform 5]: Expressed specifically in striated muscle (skeletal and cardiac muscle).
科研貨號： PLA000290

Phospho Integrin β1 (T789) Cell-Based Colorimetric ELISA Kit

Catalog No PLA000290

Product information

發(fā)貨日期： 14
基因名稱： ITGB1
Human_gene_id： 3688
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3688
Human_swiss_prot_no： P05556
Human_swiss_link： http://www.uniprot.org/uniprotkb/P05556/entry
Mouse_swiss_prot_no： P09055
Mouse_swiss_link： http://www.uniprot.org/uniprot/P09055
Rat_swiss_prot_no： P49134
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P49134
儲存： 2-8°C/6 months
說明書： KA1288C.pdf
其他名稱： Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29)
功能： G1/S transition of mitotic cell cycle,?mitotic cell cycle,?in utero embryonic development,?cell fate specification,?cell activation,?immune system development,?leukocyte differentiation,?cell motion,?defense response,?cellular defense response,?cytoskeleton organization,?cell cycle,?cell adhesion,?homophilic cell adhesion,?leukocyte adhesion,?cell-matrix adhesion,?cell surface receptor linked signal transduction,?integrin-mediated signaling pathway,?gamete generation,heart development,?muscle organ development,?positive regulation of cell proliferation,?germ cell migration,?embryonic development ending in birth or egg hatching,?cellular component assembly involved in morphogenesis,?striated muscle tissue development,?cell-cell adhesion,?cell migration,?sexual reproduction,?cell cycle process,?cell cycle phase,biological adhesion,?actin filament-based process,?actin cytoskeleton organization,?hemopoiesis,?lymphocyte differentiation,?B cell differentiation,?myofibril assembly,?actomyosin structure organization,?cell-substrate adhesion,multicellular organism reproduction,?cellular component morphogenesis,?cell adhesion mediated by integrin,?cell-cell adhesion mediated by integrin,?cardiac cell differentiation,?B cell activation,?regulation of cell proliferation,?muscle cell differentiation,?chordate embryonic development,?cell fate commitment,?sarcomere organization,?leukocyte activation,negative regulation of cell differentiation,?lymphocyte activation,?hemopoietic or lymphoid organ development,reproductive process in a multicellular organism,?reproductive cellular process,?cardiac muscle tissue development,?cell motility,?striated muscle cell differentiation,?interphase,?interphase of mitotic cell cycle,?localization of cell,?regulation of cell cycle,?muscle cell development,?striated muscle cell development,?cardiac muscle cell differentiation,?muscle tissue development,
相關產品： YT5583,YT2368,YT2367,YT2366,YP0879,YP0496,YP0143,KA4139C,KA1773C,KA1288C,KA1262C
細胞定位： Cell membrane ; Single-pass type I membrane protein . Cell projection, invadopodium membrane ; Single-pass type I membrane protein . Cell projection, ruffle membrane ; Single-pass type I membrane protein . Recycling endosome . Melanosome . Cleavage furrow . Cell projection, lamellipodium . Cell projection, ruffle . Cell junction, focal adhesion . Cell surface . Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. .; [Isoform 5]: Cell membrane, sarcolemma . Cell junction . In cardiac muscle, isoform 5 is found in costameres and intercalated disks. .
組織表達： [Isoform 1]: Widely expressed, other isoforms are generally coexpressed with a more restricted distribution. ; [Isoform 2]: Expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. ; [Isoform 3]: Together with isoform 4, is expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. ; [Isoform 4]: Together with isoform 3, is expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Rather than isoform 3, is selectively expressed in peripheral T-cells. ; [Isoform 5]: Expressed specifically in striated muscle (skeletal and cardiac muscle).
科研貨號： PLA000290

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