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ASK 1 Monoclonal Antibody

商品貨號： PLA004651

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： MAP3K5
蛋白名稱： Mitogen-activated protein kinase kinase kinase 5
Human_gene_id： 4217
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4217
Human_swiss_prot_no： Q99683
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q99683/entry
Mouse_swiss_prot_no： O35099
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35099
特異性： ASK 1 Monoclonal Antibody detects endogenous levels of ASK 1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
信號通路： SAPK_JNK; Regulation of Actin Dynamics; Cell Growth; Stem cell pathway; Cell_Cycle_G1S;Cell_Cycle_G2M_DNA; MAPK_ERK_Growth;MAPK_G_Protein; B Cell Receptor
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838, inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to, and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838.,function:Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.,induction:By TNF-alpha. Inhibited by HIV-1 Nef.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L.,tissue specificity:Abundantly expressed in heart and pancreas.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm . Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
組織表達： Abundantly expressed in heart and pancreas.
科研貨號： PLA004651

ASK 1 Monoclonal Antibody

Catalog No PLA004651

Product information

發(fā)貨日期： 7
基因名稱： MAP3K5
蛋白名稱： Mitogen-activated protein kinase kinase kinase 5
Human_gene_id： 4217
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4217
Human_swiss_prot_no： Q99683
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q99683/entry
Mouse_swiss_prot_no： O35099
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35099
特異性： ASK 1 Monoclonal Antibody detects endogenous levels of ASK 1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5
信號通路： SAPK_JNK; Regulation of Actin Dynamics; Cell Growth; Stem cell pathway; Cell_Cycle_G1S;Cell_Cycle_G2M_DNA; MAPK_ERK_Growth;MAPK_G_Protein; B Cell Receptor
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838, inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to, and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838.,function:Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.,induction:By TNF-alpha. Inhibited by HIV-1 Nef.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L.,tissue specificity:Abundantly expressed in heart and pancreas.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm . Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
組織表達： Abundantly expressed in heart and pancreas.
科研貨號： PLA004651

Hunan UPT Biotechnology Co.,Ltd

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