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ATF-2 Monoclonal Antibody

商品貨號(hào)： PLA004653

適應(yīng) 性： 人,小鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期： 7
基因名稱： ATF2
蛋白名稱： Cyclic AMP-dependent transcription factor ATF-2
Human_gene_id： 1386
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1386
Human_swiss_prot_no： P15336
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15336/entry
Mouse_gene_id： 1.00048e+008
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100047997
Mouse_swiss_prot_no： P16951
Mouse_swiss_link： http://www.uniprot.org/uniprot/P16951
特異性： ATF-2 Monoclonal Antibody detects endogenous levels of ATF-2 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： ATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding pro
信號(hào)通路： B Cell Receptor; Stem cell pathway; MAPK_ERK_Growth;MAPK_G_Protein; PI3K/Akt; Protein_Acetylation
功能： caution:It is uncertain whether Met-1 or Met-19 is the initiator.,function:Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.,PTM:Phosphorylation of Thr-69 and Thr-71 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 C2H2-type zinc finger.,subunit:Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.,tissue specificity:Abundant expression seen in the brain.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Cytoplasm. Mitochondrion outer membrane. Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
組織表達(dá)： Ubiquitously expressed, with more abundant expression in the brain.
科研貨號(hào)： PLA004653

ATF-2 Monoclonal Antibody

Catalog No PLA004653

Product information

發(fā)貨日期： 7
基因名稱： ATF2
蛋白名稱： Cyclic AMP-dependent transcription factor ATF-2
Human_gene_id： 1386
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1386
Human_swiss_prot_no： P15336
Human_swiss_link： http://www.uniprot.org/uniprotkb/P15336/entry
Mouse_gene_id： 1.00048e+008
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100047997
Mouse_swiss_prot_no： P16951
Mouse_swiss_link： http://www.uniprot.org/uniprot/P16951
特異性： ATF-2 Monoclonal Antibody detects endogenous levels of ATF-2 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： ATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding pro
信號(hào)通路： B Cell Receptor; Stem cell pathway; MAPK_ERK_Growth;MAPK_G_Protein; PI3K/Akt; Protein_Acetylation
功能： caution:It is uncertain whether Met-1 or Met-19 is the initiator.,function:Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.,PTM:Phosphorylation of Thr-69 and Thr-71 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 C2H2-type zinc finger.,subunit:Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.,tissue specificity:Abundant expression seen in the brain.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Cytoplasm. Mitochondrion outer membrane. Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
組織表達(dá)： Ubiquitously expressed, with more abundant expression in the brain.
科研貨號(hào)： PLA004653

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