信號通路： Amino sugar and nucleotide sugar metabolism;
功能： catalytic activity:Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.,disease:Very high plasma levels of CHIT1 are found in patients with Gaucher disease type 1 (GD I). This can be used as diagnostic aid and to evaluate the success of treatment. Successful therapy brings the CHIT1 activity levels back to normal.,function:Degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.,polymorphism:A 24 bp duplication in exon 10 leads to the activation of an alternative splice site and the production of an inactive protein. About 6% of the population are deficient for CHIT1 activity, while 35% are carriers and show reduced enzyme levels. People with CHIT1 deficiency appear perfectly healthy.,similarity:Belongs to the glycosyl hydrolase 18 family.,similarity:Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.,similarity:Contains 1 chitin-binding type-2 domain.,subcellular location:A small proportion is lysosomal.,subunit:Monomer.,tissue specificity:Detected in spleen. Secreted by cultured macrophages.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Secreted. Lysosome. A small proportion is lysosomal.
組織表達： Detected in spleen. Secreted by cultured macrophages.
信號通路： Amino sugar and nucleotide sugar metabolism;
功能： catalytic activity:Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.,disease:Very high plasma levels of CHIT1 are found in patients with Gaucher disease type 1 (GD I). This can be used as diagnostic aid and to evaluate the success of treatment. Successful therapy brings the CHIT1 activity levels back to normal.,function:Degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.,polymorphism:A 24 bp duplication in exon 10 leads to the activation of an alternative splice site and the production of an inactive protein. About 6% of the population are deficient for CHIT1 activity, while 35% are carriers and show reduced enzyme levels. People with CHIT1 deficiency appear perfectly healthy.,similarity:Belongs to the glycosyl hydrolase 18 family.,similarity:Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.,similarity:Contains 1 chitin-binding type-2 domain.,subcellular location:A small proportion is lysosomal.,subunit:Monomer.,tissue specificity:Detected in spleen. Secreted by cultured macrophages.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Secreted. Lysosome. A small proportion is lysosomal.
組織表達： Detected in spleen. Secreted by cultured macrophages.
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