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EHMT1 Monoclonal Antibody

商品貨號(hào)： PLA004765

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書

商品描述

發(fā)貨日期： 7
基因名稱： EHMT1
蛋白名稱： Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
Human_gene_id： 79813
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79813
Human_swiss_prot_no： Q9H9B1
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9H9B1/entry
Mouse_swiss_prot_no： Q5DW34
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q5DW34
特異性： EHMT1 Monoclonal Antibody detects endogenous levels of EHMT1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： EHMT1; EUHMTASE1; GLP; KIAA1876; KMT1D; Histone-lysine N-methyltransferase EHMT1; Euchromatic histone-lysine N-methyltransferase 1; Eu-HMTase1; G9a-like protein 1; GLP; GLP1; Histone H3-K9 methyltransferase 5; H3-K9-HMTase 5; Lysine N-methy
信號(hào)通路： Lysine degradation;
功能： alternative products:Experimental confirmation may be lacking for some isoforms,catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,disease:Defects in EHMT1 are the cause of chromosome 9q subtelomeric deletion syndrome (9q- syndrome) [MIM:610253]. Common features seen in these patients are severe mental retardation, hypotonia, brachy(micro)cephaly, epileptic seizures, flat face with hypertelorism, synophrys, anteverted nares, cupid bow or tented upper lip, everted lower lip, prognathism, macroglossia, conotruncal heart defects, and behavioral problems.,domain:The SET domain mediates interaction with WIZ.,function:Histone methyltransferase. Methylates 'Lys-9' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Intron retention.,similarity:Belongs to the histone-lysine methyltransferase family.,similarity:Contains 1 pre-SET domain.,similarity:Contains 1 SET domain.,similarity:Contains 8 ANK repeats.,subcellular location:Associates with euchromatic regions.,subunit:Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with WIZ and EHMT2.,tissue specificity:Widely expressed.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Chromosome. Associates with euchromatic regions.
組織表達(dá)： Widely expressed.
科研貨號(hào)： PLA004765

EHMT1 Monoclonal Antibody

Catalog No PLA004765

Product information

發(fā)貨日期： 7
基因名稱： EHMT1
蛋白名稱： Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
Human_gene_id： 79813
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79813
Human_swiss_prot_no： Q9H9B1
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9H9B1/entry
Mouse_swiss_prot_no： Q5DW34
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q5DW34
特異性： EHMT1 Monoclonal Antibody detects endogenous levels of EHMT1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： EHMT1; EUHMTASE1; GLP; KIAA1876; KMT1D; Histone-lysine N-methyltransferase EHMT1; Euchromatic histone-lysine N-methyltransferase 1; Eu-HMTase1; G9a-like protein 1; GLP; GLP1; Histone H3-K9 methyltransferase 5; H3-K9-HMTase 5; Lysine N-methy
信號(hào)通路： Lysine degradation;
功能： alternative products:Experimental confirmation may be lacking for some isoforms,catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,disease:Defects in EHMT1 are the cause of chromosome 9q subtelomeric deletion syndrome (9q- syndrome) [MIM:610253]. Common features seen in these patients are severe mental retardation, hypotonia, brachy(micro)cephaly, epileptic seizures, flat face with hypertelorism, synophrys, anteverted nares, cupid bow or tented upper lip, everted lower lip, prognathism, macroglossia, conotruncal heart defects, and behavioral problems.,domain:The SET domain mediates interaction with WIZ.,function:Histone methyltransferase. Methylates 'Lys-9' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Intron retention.,similarity:Belongs to the histone-lysine methyltransferase family.,similarity:Contains 1 pre-SET domain.,similarity:Contains 1 SET domain.,similarity:Contains 8 ANK repeats.,subcellular location:Associates with euchromatic regions.,subunit:Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with WIZ and EHMT2.,tissue specificity:Widely expressed.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Chromosome. Associates with euchromatic regions.
組織表達(dá)： Widely expressed.
科研貨號(hào)： PLA004765

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