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Fibrinogen β Monoclonal Antibody

商品貨號(hào)： PLA004803

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書

商品描述

發(fā)貨日期： 7
基因名稱： FGB
蛋白名稱： Fibrinogen beta chain
Human_gene_id： 2244
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2244
Human_swiss_prot_no： P02675
Human_swiss_link： http://www.uniprot.org/uniprotkb/P02675/entry
Mouse_swiss_prot_no： Q8K0E8
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8K0E8
特異性： Fibrinogen β Monoclonal Antibody detects endogenous levels of Fibrinogen β protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： FGB; Fibrinogen beta chain
信號(hào)通路： Complement and coagulation cascades;
功能： disease:Defects in FGB are a cause of congenital afibrinogenemia [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.,disease:Defects in FGB are a cause of thrombophilia.,domain:A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.,function:Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.,online information:Fibrinogen entry,online information:The Singapore human mutation and polymorphism database,PTM:Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.,similarity:Contains 1 fibrinogen C-terminal domain.,subunit:Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Secreted .
組織表達(dá)： Detected in blood plasma (at protein level).
科研貨號(hào)： PLA004803

Fibrinogen β Monoclonal Antibody

Catalog No PLA004803

Product information

發(fā)貨日期： 7
基因名稱： FGB
蛋白名稱： Fibrinogen beta chain
Human_gene_id： 2244
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2244
Human_swiss_prot_no： P02675
Human_swiss_link： http://www.uniprot.org/uniprotkb/P02675/entry
Mouse_swiss_prot_no： Q8K0E8
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q8K0E8
特異性： Fibrinogen β Monoclonal Antibody detects endogenous levels of Fibrinogen β protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： FGB; Fibrinogen beta chain
信號(hào)通路： Complement and coagulation cascades;
功能： disease:Defects in FGB are a cause of congenital afibrinogenemia [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.,disease:Defects in FGB are a cause of thrombophilia.,domain:A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.,function:Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.,online information:Fibrinogen entry,online information:The Singapore human mutation and polymorphism database,PTM:Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.,similarity:Contains 1 fibrinogen C-terminal domain.,subunit:Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Secreted .
組織表達(dá)： Detected in blood plasma (at protein level).
科研貨號(hào)： PLA004803

Hunan UPT Biotechnology Co.,Ltd

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