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GSK3β Monoclonal Antibody

商品貨號(hào)： PLA004840

適應(yīng) 性： 人,小鼠,大鼠,猴

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： GSK3B
蛋白名稱： Glycogen synthase kinase-3 beta
Human_gene_id： 2942
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2942
Human_swiss_prot_no： P49841
Human_swiss_link： http://www.uniprot.org/uniprotkb/P49841/entry
Mouse_gene_id： 56637
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56637
Mouse_swiss_prot_no： Q9WV60
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WV60
Rat_gene_id： 84027
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84027
Rat_swiss_prot_no： P18266
Rat_swiss_link： http://www.uniprot.org/uniprot/P18266
特異性： GSK3β Monoclonal Antibody detects endogenous levels of GSK3β protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
信號(hào)通路： ErbB_HER;Chemokine;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;WNT;WNT-T CELLHedgehog;Axon guidance;Focal adhesion;T_Cell_Receptor;B_Cell_Antigen;Neurotrophin;Insulin_Receptor;Melanogenesis;Alzheimer's disease;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Basal cell carcinoma;
功能： catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .
組織表達(dá)： Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
科研貨號(hào)： PLA004840

GSK3β Monoclonal Antibody

Catalog No PLA004840

Product information

基因名稱： GSK3B
蛋白名稱： Glycogen synthase kinase-3 beta
Human_gene_id： 2942
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2942
Human_swiss_prot_no： P49841
Human_swiss_link： http://www.uniprot.org/uniprotkb/P49841/entry
Mouse_gene_id： 56637
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56637
Mouse_swiss_prot_no： Q9WV60
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WV60
Rat_gene_id： 84027
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84027
Rat_swiss_prot_no： P18266
Rat_swiss_link： http://www.uniprot.org/uniprot/P18266
特異性： GSK3β Monoclonal Antibody detects endogenous levels of GSK3β protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
信號(hào)通路： ErbB_HER;Chemokine;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;WNT;WNT-T CELLHedgehog;Axon guidance;Focal adhesion;T_Cell_Receptor;B_Cell_Antigen;Neurotrophin;Insulin_Receptor;Melanogenesis;Alzheimer's disease;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Basal cell carcinoma;
功能： catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .
組織表達(dá)： Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
科研貨號(hào)： PLA004840

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