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MEK-2 Monoclonal Antibody

商品貨號(hào)： PLA004928

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期： 7
基因名稱： MAP2K2
蛋白名稱： Dual specificity mitogen-activated protein kinase kinase 2
Human_gene_id： 5605
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5605
Human_swiss_prot_no： P36507
Human_swiss_link： http://www.uniprot.org/uniprotkb/P36507/entry
Mouse_gene_id： 26396
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26396
Mouse_swiss_prot_no： Q63932
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q63932
Rat_gene_id： 58960
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58960
Rat_swiss_prot_no： P36506
Rat_swiss_link： http://www.uniprot.org/uniprot/P36506
特異性： MEK-2 Monoclonal Antibody detects endogenous levels of MEK-2 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
信號(hào)通路： Regulates Angiogenesis; Regulation of Actin Dynamics; Stem cell pathway; T_Cell_Receptor; Insulin Receptor; Cell Growth; Toll_Like; MAPK_ERK_Growth;MAPK_G_Protein; B_Cell_Antigen; PI3K/Akt
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.,function:Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.,PTM:MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MORG1.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Membrane ; Peripheral membrane protein . Membrane localization is probably regulated by its interaction with KSR1. .
組織表達(dá)： Colon carcinoma,Epithelium,Human cerebellum,Muscle,Platelet
科研貨號(hào)： PLA004928

MEK-2 Monoclonal Antibody

Catalog No PLA004928

Product information

發(fā)貨日期： 7
基因名稱： MAP2K2
蛋白名稱： Dual specificity mitogen-activated protein kinase kinase 2
Human_gene_id： 5605
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5605
Human_swiss_prot_no： P36507
Human_swiss_link： http://www.uniprot.org/uniprotkb/P36507/entry
Mouse_gene_id： 26396
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26396
Mouse_swiss_prot_no： Q63932
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q63932
Rat_gene_id： 58960
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58960
Rat_swiss_prot_no： P36506
Rat_swiss_link： http://www.uniprot.org/uniprot/P36506
特異性： MEK-2 Monoclonal Antibody detects endogenous levels of MEK-2 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
信號(hào)通路： Regulates Angiogenesis; Regulation of Actin Dynamics; Stem cell pathway; T_Cell_Receptor; Insulin Receptor; Cell Growth; Toll_Like; MAPK_ERK_Growth;MAPK_G_Protein; B_Cell_Antigen; PI3K/Akt
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.,function:Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.,PTM:MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MORG1.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Membrane ; Peripheral membrane protein . Membrane localization is probably regulated by its interaction with KSR1. .
組織表達(dá)： Colon carcinoma,Epithelium,Human cerebellum,Muscle,Platelet
科研貨號(hào)： PLA004928

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