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PRMT4 Monoclonal Antibody

商品貨號： PLA004999

適應(yīng) 性： 人,大鼠,猴

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： CARM1
蛋白名稱： Histone-arginine methyltransferase CARM1
Human_gene_id： 10498
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10498
Human_swiss_prot_no： Q86X55
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q86X55/entry
Mouse_swiss_prot_no： Q9WVG6
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WVG6
Rat_gene_id： 363026
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363026
Rat_swiss_prot_no： Q4AE70
Rat_swiss_link： http://www.uniprot.org/uniprot/Q4AE70
特異性： PRMT4 Monoclonal Antibody detects endogenous levels of PRMT4 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： CARM1; PRMT4; Histone-arginine methyltransferase CARM1; Coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4
功能： catalytic activity:S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N(omega)-methyl-arginine.,function:Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' and activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.,miscellaneous:Methylation of H3-R17 by CARM1 is stimulated by preacetylation of H3-K18/H3-K23 by EP300 and blocked by citrullination of H3-R17 by PADI4.,similarity:Belongs to the protein arginine N-methyltransferase family.,subunit:Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, CREBBP and CTNNB1. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA. Interacts with HTLV-1 Tax-1.,tissue specificity:Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.,
相關(guān)產(chǎn)品： YM1215,YM1085,YM0535,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Cytoplasm . Mainly nuclear during the G1, S and G2 phases of the cell cycle (PubMed:19843527). Cytoplasmic during mitosis, after breakup of the nuclear membrane (PubMed:19843527). .
組織表達(dá)： Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
科研貨號： PLA004999

PRMT4 Monoclonal Antibody

Catalog No PLA004999

Product information

發(fā)貨日期： 7
基因名稱： CARM1
蛋白名稱： Histone-arginine methyltransferase CARM1
Human_gene_id： 10498
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10498
Human_swiss_prot_no： Q86X55
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q86X55/entry
Mouse_swiss_prot_no： Q9WVG6
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WVG6
Rat_gene_id： 363026
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363026
Rat_swiss_prot_no： Q4AE70
Rat_swiss_link： http://www.uniprot.org/uniprot/Q4AE70
特異性： PRMT4 Monoclonal Antibody detects endogenous levels of PRMT4 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： CARM1; PRMT4; Histone-arginine methyltransferase CARM1; Coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4
功能： catalytic activity:S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N(omega)-methyl-arginine.,function:Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' and activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.,miscellaneous:Methylation of H3-R17 by CARM1 is stimulated by preacetylation of H3-K18/H3-K23 by EP300 and blocked by citrullination of H3-R17 by PADI4.,similarity:Belongs to the protein arginine N-methyltransferase family.,subunit:Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, CREBBP and CTNNB1. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA. Interacts with HTLV-1 Tax-1.,tissue specificity:Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.,
相關(guān)產(chǎn)品： YM1215,YM1085,YM0535,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus . Cytoplasm . Mainly nuclear during the G1, S and G2 phases of the cell cycle (PubMed:19843527). Cytoplasmic during mitosis, after breakup of the nuclear membrane (PubMed:19843527). .
組織表達(dá)： Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
科研貨號： PLA004999

Hunan UPT Biotechnology Co.,Ltd

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