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Rb Monoclonal Antibody

商品貨號： PLA005012

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： RB1
蛋白名稱： Retinoblastoma-associated protein
Human_gene_id： 5925
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5925
Human_swiss_prot_no： P06400
Human_swiss_link： http://www.uniprot.org/uniprotkb/P06400/entry
Mouse_swiss_prot_no： P13405
Mouse_swiss_link： http://www.uniprot.org/uniprot/P13405
特異性： Rb Monoclonal Antibody detects endogenous levels of Rb protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
信號通路： Stem cell pathway; Cell_Cycle_G1S;Cell_Cycle_G2M_DNA; Protein_Acetylation
功能： disease:Defects in RB1 are a cause of bladder cancer [MIM:109800].,disease:Defects in RB1 are a cause of osteogenic sarcoma [MIM:259500].,disease:Defects in RB1 are the cause of childhood cancer retinoblastoma (RB) [MIM:180200]. RB is a congenital malignant tumor that arises from the nuclear layers of the retina. It occurs in about 1:20'000 live births and represents about 2% of childhood malignancies. It is bilateral in about 30% of cases. Although most RB appear sporadically, about 20% are transmitted as an autosomal dominant trait with incomplete penetrance. The diagnosis is usually made before the age of 2 years when strabismus or a gray to yellow reflex from pupil ("cat eye") is investigated.,function:Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.,online information:RB1 mutation db,online information:Retinoblastoma protein entry,PTM:Phosphorylated in G1, thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. SV40 large T antigen, HPV E7 and adenovirus E1A bind to the underphosphorylated, active form of pRb.,similarity:Belongs to the retinoblastoma protein (RB) family.,subunit:Interacts with ATAD5 (By similarity). The hypophosphorylated form interacts with and sequesters the E2F1 transcription factor. The unphosphorylated form interacts with ARID3B, KDM5A, SUV39H1, MJD2A/JHDM3A and THOC1. Interacts with the N-terminal domain of TAF1. Interacts with AATF, DNMT1, LIN9, LMNA, SUV420H1, SUV420H2, PELP1 and TMPO-alpha. May interact with NDC80. Interacts with EID1 and UBR4. Interacts with ARID4A and KDM5B. Interacts with E4F1. Interacts with adenovirus E1A protein, HPV E7 protein and SV40 large T antigen.,tissue specificity:Expressed in the retina.,
相關(guān)產(chǎn)品： YT5696,YT4023,YT4022,YT4021,YT4020,YT4019,YT4018,YT4017,YT4016,YT4015,YP1184,YP1137,YP1033,YP0995,YP0774,YP0556,YP0539,YP0242,YP0241,YP0240,YK0092,KA4266C,KA1688C,KA1646C,KA1645C,KA1644C,KA1471C,KA1417C
細(xì)胞定位： Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .
組織表達(dá)： Expressed in the retina. Expressed in foreskin keratinocytes (at protein level) (PubMed:20940255).
科研貨號： PLA005012

Rb Monoclonal Antibody

Catalog No PLA005012

Product information

發(fā)貨日期： 7
基因名稱： RB1
蛋白名稱： Retinoblastoma-associated protein
Human_gene_id： 5925
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5925
Human_swiss_prot_no： P06400
Human_swiss_link： http://www.uniprot.org/uniprotkb/P06400/entry
Mouse_swiss_prot_no： P13405
Mouse_swiss_link： http://www.uniprot.org/uniprot/P13405
特異性： Rb Monoclonal Antibody detects endogenous levels of Rb protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
信號通路： Stem cell pathway; Cell_Cycle_G1S;Cell_Cycle_G2M_DNA; Protein_Acetylation
功能： disease:Defects in RB1 are a cause of bladder cancer [MIM:109800].,disease:Defects in RB1 are a cause of osteogenic sarcoma [MIM:259500].,disease:Defects in RB1 are the cause of childhood cancer retinoblastoma (RB) [MIM:180200]. RB is a congenital malignant tumor that arises from the nuclear layers of the retina. It occurs in about 1:20'000 live births and represents about 2% of childhood malignancies. It is bilateral in about 30% of cases. Although most RB appear sporadically, about 20% are transmitted as an autosomal dominant trait with incomplete penetrance. The diagnosis is usually made before the age of 2 years when strabismus or a gray to yellow reflex from pupil ("cat eye") is investigated.,function:Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.,online information:RB1 mutation db,online information:Retinoblastoma protein entry,PTM:Phosphorylated in G1, thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. SV40 large T antigen, HPV E7 and adenovirus E1A bind to the underphosphorylated, active form of pRb.,similarity:Belongs to the retinoblastoma protein (RB) family.,subunit:Interacts with ATAD5 (By similarity). The hypophosphorylated form interacts with and sequesters the E2F1 transcription factor. The unphosphorylated form interacts with ARID3B, KDM5A, SUV39H1, MJD2A/JHDM3A and THOC1. Interacts with the N-terminal domain of TAF1. Interacts with AATF, DNMT1, LIN9, LMNA, SUV420H1, SUV420H2, PELP1 and TMPO-alpha. May interact with NDC80. Interacts with EID1 and UBR4. Interacts with ARID4A and KDM5B. Interacts with E4F1. Interacts with adenovirus E1A protein, HPV E7 protein and SV40 large T antigen.,tissue specificity:Expressed in the retina.,
相關(guān)產(chǎn)品： YT5696,YT4023,YT4022,YT4021,YT4020,YT4019,YT4018,YT4017,YT4016,YT4015,YP1184,YP1137,YP1033,YP0995,YP0774,YP0556,YP0539,YP0242,YP0241,YP0240,YK0092,KA4266C,KA1688C,KA1646C,KA1645C,KA1644C,KA1471C,KA1417C
細(xì)胞定位： Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .
組織表達(dá)： Expressed in the retina. Expressed in foreskin keratinocytes (at protein level) (PubMed:20940255).
科研貨號： PLA005012

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