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SOX-2 Monoclonal Antibody

商品貨號(hào)： PLA005044

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： SOX2
蛋白名稱： Transcription factor SOX-2
Human_gene_id： 6657
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6657
Human_swiss_prot_no： P48431
Human_swiss_link： http://www.uniprot.org/uniprotkb/P48431/entry
Mouse_swiss_prot_no： P48432
Mouse_swiss_link： http://www.uniprot.org/uniprot/P48432
特異性： SOX-2 Monoclonal Antibody detects endogenous levels of SOX-2 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： SOX2; Transcription factor SOX-2
功能： disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.,similarity:Contains 1 HMG box DNA-binding domain.,
相關(guān)產(chǎn)品： YM1221,YM1099,YM0594,YM0593
細(xì)胞定位： Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). .
組織表達(dá)： Fetal brain,Lung,Retina,
tag： hot
科研貨號(hào)： PLA005044

SOX-2 Monoclonal Antibody

Catalog No PLA005044

Product information

發(fā)貨日期： 7
基因名稱： SOX2
蛋白名稱： Transcription factor SOX-2
Human_gene_id： 6657
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6657
Human_swiss_prot_no： P48431
Human_swiss_link： http://www.uniprot.org/uniprotkb/P48431/entry
Mouse_swiss_prot_no： P48432
Mouse_swiss_link： http://www.uniprot.org/uniprot/P48432
特異性： SOX-2 Monoclonal Antibody detects endogenous levels of SOX-2 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： SOX2; Transcription factor SOX-2
功能： disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.,similarity:Contains 1 HMG box DNA-binding domain.,
相關(guān)產(chǎn)品： YM1221,YM1099,YM0594,YM0593
細(xì)胞定位： Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). .
組織表達(dá)： Fetal brain,Lung,Retina,
tag： hot
科研貨號(hào)： PLA005044

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