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HDAC4 Monoclonal Antibody

商品貨號(hào)： PLA005111

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期： 7
基因名稱： HDAC4
蛋白名稱： Histone deacetylase 4
Human_gene_id： 9759
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9759
Human_swiss_prot_no： P56524
Human_swiss_link： http://www.uniprot.org/uniprotkb/P56524/entry
Mouse_gene_id： 208727
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=208727
Mouse_swiss_prot_no： Q6NZM9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6NZM9
Rat_gene_id： 363287
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363287
Rat_swiss_prot_no： Q99P99
Rat_swiss_link： http://www.uniprot.org/uniprot/Q99P99
特異性： HDAC4 Monoclonal Antibody detects endogenous levels of HDAC4 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： HDAC4; KIAA0288; Histone deacetylase 4; HD4
信號(hào)通路： Protein_Acetylation
功能： catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,domain:The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.,PTM:Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues is required for the interaction with 14-3-3.,PTM:Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.,similarity:Belongs to the histone deacetylase family. Type 2 subfamily.,subcellular location:Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4. The nuclear localization probably depends on sumoylation.,subunit:Interacts with HDAC7 (By similarity). Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B (By similarity). Interacts with KDM5B.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). .
組織表達(dá)： Ubiquitous.
科研貨號(hào)： PLA005111

HDAC4 Monoclonal Antibody

Catalog No PLA005111

Product information

發(fā)貨日期： 7
基因名稱： HDAC4
蛋白名稱： Histone deacetylase 4
Human_gene_id： 9759
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9759
Human_swiss_prot_no： P56524
Human_swiss_link： http://www.uniprot.org/uniprotkb/P56524/entry
Mouse_gene_id： 208727
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=208727
Mouse_swiss_prot_no： Q6NZM9
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6NZM9
Rat_gene_id： 363287
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363287
Rat_swiss_prot_no： Q99P99
Rat_swiss_link： http://www.uniprot.org/uniprot/Q99P99
特異性： HDAC4 Monoclonal Antibody detects endogenous levels of HDAC4 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： HDAC4; KIAA0288; Histone deacetylase 4; HD4
信號(hào)通路： Protein_Acetylation
功能： catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,domain:The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.,PTM:Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues is required for the interaction with 14-3-3.,PTM:Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.,similarity:Belongs to the histone deacetylase family. Type 2 subfamily.,subcellular location:Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4. The nuclear localization probably depends on sumoylation.,subunit:Interacts with HDAC7 (By similarity). Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B (By similarity). Interacts with KDM5B.,tissue specificity:Ubiquitous.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). .
組織表達(dá)： Ubiquitous.
科研貨號(hào)： PLA005111

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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