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IκB-α Monoclonal Antibody

商品貨號(hào)： PLA005121

適應(yīng) 性： 人,小鼠,大鼠,豬,綿羊

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

發(fā)貨日期： 7
基因名稱(chēng)： NFKBIA IKBA MAD3 NFKBI
蛋白名稱(chēng)： NF-kappa-B inhibitor alpha
Human_gene_id： 4792
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4792
Human_swiss_prot_no： P25963
Human_swiss_link： http://www.uniprot.org/uniprotkb/P25963/entry
Mouse_gene_id： 18035
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18035
Mouse_swiss_prot_no： Q9Z1E3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z1E3
Rat_gene_id： 25493
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25493
Rat_swiss_prot_no： Q63746
Rat_swiss_link： http://www.uniprot.org/uniprot/Q63746
特異性： IκB-α Monoclonal Antibody detects endogenous levels of IκB-α protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋?zhuān)? WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱(chēng)： NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
信號(hào)通路： Chemokine;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Toll_Like;NOD-like receptor;RIG-I-like receptor;Cytosolic DNA-sensing pathway;T_Cell_Receptor;B_Cell_Antigen;Neurotrophin;Adipocytokine;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Prostate cancer;Chronic myeloid leukemia;Small cell lung cancer;
功能： disease:Defects in NFKBIA are the cause of ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant (ADEDAID) [MIM:612132]. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADEDAID is an ectodermal dysplasia associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection.,function:Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.,induction:Induced in adherent monocytes.,online information:NFKBIA mutation db,PTM:Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity.,PTM:Sumoylated; sumoylation requires the presence of the nuclear import signal.,PTM:Ubiquitinated; subsequent to stimulus-dependent phosphorylation on serines.,similarity:Belongs to the NF-kappa-B inhibitor family.,similarity:Contains 5 ANK repeats.,subcellular location:Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.,subunit:Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. .
組織表達(dá)： Brain,Kidney,Lymph node,Monocyte,
科研貨號(hào)： PLA005121

IκB-α Monoclonal Antibody

Catalog No PLA005121

Product information

發(fā)貨日期： 7
基因名稱(chēng)： NFKBIA IKBA MAD3 NFKBI
蛋白名稱(chēng)： NF-kappa-B inhibitor alpha
Human_gene_id： 4792
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4792
Human_swiss_prot_no： P25963
Human_swiss_link： http://www.uniprot.org/uniprotkb/P25963/entry
Mouse_gene_id： 18035
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18035
Mouse_swiss_prot_no： Q9Z1E3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z1E3
Rat_gene_id： 25493
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25493
Rat_swiss_prot_no： Q63746
Rat_swiss_link： http://www.uniprot.org/uniprot/Q63746
特異性： IκB-α Monoclonal Antibody detects endogenous levels of IκB-α protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋?zhuān)? WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱(chēng)： NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
信號(hào)通路： Chemokine;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Toll_Like;NOD-like receptor;RIG-I-like receptor;Cytosolic DNA-sensing pathway;T_Cell_Receptor;B_Cell_Antigen;Neurotrophin;Adipocytokine;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Prostate cancer;Chronic myeloid leukemia;Small cell lung cancer;
功能： disease:Defects in NFKBIA are the cause of ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant (ADEDAID) [MIM:612132]. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADEDAID is an ectodermal dysplasia associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection.,function:Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.,induction:Induced in adherent monocytes.,online information:NFKBIA mutation db,PTM:Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity.,PTM:Sumoylated; sumoylation requires the presence of the nuclear import signal.,PTM:Ubiquitinated; subsequent to stimulus-dependent phosphorylation on serines.,similarity:Belongs to the NF-kappa-B inhibitor family.,similarity:Contains 5 ANK repeats.,subcellular location:Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.,subunit:Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. .
組織表達(dá)： Brain,Kidney,Lymph node,Monocyte,
科研貨號(hào)： PLA005121

Hunan UPT Biotechnology Co.,Ltd

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