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PP1α Monoclonal Antibody

商品貨號： PLA005136

適應(yīng) 性： 人,小鼠,大鼠,牛,雞,豬,兔,斑馬魚

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： PPP1CA
蛋白名稱： Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Human_gene_id： 5499
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5499
Human_swiss_prot_no： P62136
Human_swiss_link： http://www.uniprot.org/uniprotkb/P62136/entry
Mouse_gene_id： 19045
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19045
Mouse_swiss_prot_no： P62137
Mouse_swiss_link： http://www.uniprot.org/uniprot/P62137
Rat_gene_id： 24668
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24668
Rat_swiss_prot_no： P62138
Rat_swiss_link： http://www.uniprot.org/uniprot/P62138
特異性： PP1α Monoclonal Antibody detects endogenous levels of PP1α protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PPP1CA; PPP1A; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP-1A
信號通路： Oocyte meiosis;Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Regulates Actin and Cytoskeleton;Insulin_Receptor;
功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,online information:The things we forget -Issue 32 of March 2003,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PPP1R7. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with HHV-1 ICP34.5.,
相關(guān)產(chǎn)品： YT3825,YP0974,YM0527,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus . Nucleus, nucleoplasm . Nucleus, nucleolus . Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Shuttles toward the cytosol during infection with VEEV (PubMed:29769351). .
組織表達(dá)： Colon carcinoma,Liver,Lung,Muscle,Pancreas,Placenta,Platele
tag： hot
科研貨號： PLA005136

PP1α Monoclonal Antibody

Catalog No PLA005136

Product information

發(fā)貨日期： 7
基因名稱： PPP1CA
蛋白名稱： Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Human_gene_id： 5499
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5499
Human_swiss_prot_no： P62136
Human_swiss_link： http://www.uniprot.org/uniprotkb/P62136/entry
Mouse_gene_id： 19045
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19045
Mouse_swiss_prot_no： P62137
Mouse_swiss_link： http://www.uniprot.org/uniprot/P62137
Rat_gene_id： 24668
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24668
Rat_swiss_prot_no： P62138
Rat_swiss_link： http://www.uniprot.org/uniprot/P62138
特異性： PP1α Monoclonal Antibody detects endogenous levels of PP1α protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： PPP1CA; PPP1A; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP-1A
信號通路： Oocyte meiosis;Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Regulates Actin and Cytoskeleton;Insulin_Receptor;
功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,online information:The things we forget -Issue 32 of March 2003,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PPP1R7. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with HHV-1 ICP34.5.,
相關(guān)產(chǎn)品： YT3825,YP0974,YM0527,RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus . Nucleus, nucleoplasm . Nucleus, nucleolus . Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Shuttles toward the cytosol during infection with VEEV (PubMed:29769351). .
組織表達(dá)： Colon carcinoma,Liver,Lung,Muscle,Pancreas,Placenta,Platele
tag： hot
科研貨號： PLA005136

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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