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TFIIH p89 Monoclonal Antibody

商品貨號： PLA005162

適應(yīng) 性： 人,小鼠,大鼠,牛,狗

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： ERCC3
蛋白名稱： TFIIH basal transcription factor complex helicase XPB subunit
Human_gene_id： 2071
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2071
Human_swiss_prot_no： P19447
Human_swiss_link： http://www.uniprot.org/uniprotkb/P19447/entry
Mouse_gene_id： 13872
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13872
Mouse_swiss_prot_no： P49135
Mouse_swiss_link： http://www.uniprot.org/uniprot/P49135
Rat_gene_id： 291703
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=291703
Rat_swiss_prot_no： Q4G005
Rat_swiss_link： http://www.uniprot.org/uniprot/Q4G005
特異性： TFIIH p89 Monoclonal Antibody detects endogenous levels of TFIIH p89 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： ERCC3; XPB; XPBC; TFIIH basal transcription factor complex helicase XPB subunit; Basic transcription factor 2 89 kDa subunit; BTF2 p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; TFIIH basal transcripti
信號通路： Nucleotide excision repair;
功能： disease:Defects in ERCC3 are a cause of trichothiodystrophy photosensitive (TTDP) [MIM:601675]. TTDP is an autosomal recessive disease characterized by sulfur-deficient brittle hair and nails, ichthyosis, mental retardation, impaired sexual development, abnormal facies and cutaneous photosensitivity correlated with a nucleotide excision repair (NER) defect. Neonates with trichothiodystrophy and ichthyosis are usually born with a collodion membrane. The severity of the ichthyosis after the membrane is shed is variable, ranging from a mild to severe lamellar ichthyotic phenotype. There are no reports of skin cancer associated with TTDP.,disease:Defects in ERCC3 are the cause of xeroderma pigmentosum complementation group B (XP-B) [MIM:610651]; also known as xeroderma pigmentosum II (XP2) or XP group B (XPB) or xeroderma pigmentosum group B combined with Cockayne syndrome (XP-B/CS). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-B patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities.,function:ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.,similarity:Belongs to the helicase family. RAD25/XPB subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:One of the six subunits forming the core-TFIIH basal transcription factor. Interacts with PUF60. Interacts with Epstein-Barr virus EBNA2.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus.
組織表達(dá)： Adipose tissue,Epithelium,Placenta,
科研貨號： PLA005162

TFIIH p89 Monoclonal Antibody

Catalog No PLA005162

Product information

發(fā)貨日期： 7
基因名稱： ERCC3
蛋白名稱： TFIIH basal transcription factor complex helicase XPB subunit
Human_gene_id： 2071
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2071
Human_swiss_prot_no： P19447
Human_swiss_link： http://www.uniprot.org/uniprotkb/P19447/entry
Mouse_gene_id： 13872
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13872
Mouse_swiss_prot_no： P49135
Mouse_swiss_link： http://www.uniprot.org/uniprot/P49135
Rat_gene_id： 291703
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=291703
Rat_swiss_prot_no： Q4G005
Rat_swiss_link： http://www.uniprot.org/uniprot/Q4G005
特異性： TFIIH p89 Monoclonal Antibody detects endogenous levels of TFIIH p89 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
純化工藝： Affinity purification
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： ERCC3; XPB; XPBC; TFIIH basal transcription factor complex helicase XPB subunit; Basic transcription factor 2 89 kDa subunit; BTF2 p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; TFIIH basal transcripti
信號通路： Nucleotide excision repair;
功能： disease:Defects in ERCC3 are a cause of trichothiodystrophy photosensitive (TTDP) [MIM:601675]. TTDP is an autosomal recessive disease characterized by sulfur-deficient brittle hair and nails, ichthyosis, mental retardation, impaired sexual development, abnormal facies and cutaneous photosensitivity correlated with a nucleotide excision repair (NER) defect. Neonates with trichothiodystrophy and ichthyosis are usually born with a collodion membrane. The severity of the ichthyosis after the membrane is shed is variable, ranging from a mild to severe lamellar ichthyotic phenotype. There are no reports of skin cancer associated with TTDP.,disease:Defects in ERCC3 are the cause of xeroderma pigmentosum complementation group B (XP-B) [MIM:610651]; also known as xeroderma pigmentosum II (XP2) or XP group B (XPB) or xeroderma pigmentosum group B combined with Cockayne syndrome (XP-B/CS). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-B patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities.,function:ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.,similarity:Belongs to the helicase family. RAD25/XPB subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:One of the six subunits forming the core-TFIIH basal transcription factor. Interacts with PUF60. Interacts with Epstein-Barr virus EBNA2.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Nucleus.
組織表達(dá)： Adipose tissue,Epithelium,Placenta,
科研貨號： PLA005162

Hunan UPT Biotechnology Co.,Ltd

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