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PPP1A mouse mAb

商品貨號： PLA005189

適應性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： ppp1ca
Human_gene_id： 5499
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5499
Human_swiss_prot_no： P62136
Human_swiss_link： http://www.uniprot.org/uniprotkb/P62136/entry
Mouse_swiss_prot_no： P62137
Mouse_swiss_link： http://www.uniprot.org/uniprot/P62137
特異性： This antibody detects endogenous levels of PPP1A and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： wb 1:1000 icc 1:300
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit; Catalytic subunit;EC 3.1.3.16;MGC15877;MGC1674;PP 1A;PP-1A;PP1A;PP1A_HUMAN;PP1alpha;PP2C ALPHA;PP2CA;Ppp1ca;Protein Phosphatase 2C Alpha Isoform;Serine threonine protein phosphatase PP1 alpha catalytic subunit;Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit.
實測條帶： 38kD
信號通路： Oocyte meiosis;Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Regulates Actin and Cytoskeleton;Insulin_Receptor;
功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,online information:The things we forget -Issue 32 of March 2003,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PPP1R7. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with HHV-1 ICP34.5.,
相關(guān)產(chǎn)品： YT3825,YP0974,YM0527,RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm . Nucleus . Nucleus, nucleoplasm . Nucleus, nucleolus . Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Shuttles toward the cytosol during infection with VEEV (PubMed:29769351). .
組織表達： Colon carcinoma,Liver,Lung,Muscle,Pancreas,Placenta,Platele
科研貨號： PLA005189

PPP1A mouse mAb

Catalog No PLA005189

Product information

發(fā)貨日期： 7
基因名稱： ppp1ca
Human_gene_id： 5499
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5499
Human_swiss_prot_no： P62136
Human_swiss_link： http://www.uniprot.org/uniprotkb/P62136/entry
Mouse_swiss_prot_no： P62137
Mouse_swiss_link： http://www.uniprot.org/uniprot/P62137
特異性： This antibody detects endogenous levels of PPP1A and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： wb 1:1000 icc 1:300
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit; Catalytic subunit;EC 3.1.3.16;MGC15877;MGC1674;PP 1A;PP-1A;PP1A;PP1A_HUMAN;PP1alpha;PP2C ALPHA;PP2CA;Ppp1ca;Protein Phosphatase 2C Alpha Isoform;Serine threonine protein phosphatase PP1 alpha catalytic subunit;Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit.
實測條帶： 38kD
信號通路： Oocyte meiosis;Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Regulates Actin and Cytoskeleton;Insulin_Receptor;
功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,online information:The things we forget -Issue 32 of March 2003,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PPP1R7. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with HHV-1 ICP34.5.,
相關(guān)產(chǎn)品： YT3825,YP0974,YM0527,RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm . Nucleus . Nucleus, nucleoplasm . Nucleus, nucleolus . Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Shuttles toward the cytosol during infection with VEEV (PubMed:29769351). .
組織表達： Colon carcinoma,Liver,Lung,Muscle,Pancreas,Placenta,Platele
科研貨號： PLA005189

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