其他名稱： Deubiquitinating enzyme 7;HAUSP;herpes virus associated;Herpes virus associated ubiquitin specific protease;Herpesvirus-associated ubiquitin-specific protease;TEF 1;tef-1;TEF1;Ubiquitin carboxyl terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin specific peptidase 7 (herpes virus associated);Ubiquitin specific peptidase 7;Ubiquitin specific peptidase 7 herpes virus associated;Ubiquitin specific processing protease 7;Ubiquitin specific protease 7 (herpes virus associated);Ubiquitin Specific Protease 7;Ubiquitin specific protease 7 herpes virus associated;Ubiquitin thioesterase 7;ubiquitin thiolesterase 7;Ubiquitin-specific-processing protease 7;UBP 7;UBP-7;UBP7;UBP7_HUMAN;USP 7;usp-7;USP7;VMW110-ASSOCIATED PROTEIN,135-KD.
實測條帶： 135kD
功能： catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,enzyme regulation:Inhibited by N-ethyl-maleimide (NEM) and divalent cations. Tolerates high concentrations of NaCl but is inhibited at concentrations of 195 mM and higher.,function:Cleaves ubiquitin fusion protein substrates. Deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis.,PTM:Polyneddylated.,PTM:Polyubiquitinated.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 MATH domain.,subcellular location:Present in a minority of ND10 nuclear bodies. Association with VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus.,subunit:Monomer. Interacts with TP53, MDM2 and UBXN6. Interacts with herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 and Epstein-Barr virus EBNA1. EBNA1 shows a 10-fold higher affinity than TP53 and can compete with it for USP7 binding. Binding to VMW110 may modulate the substrate specificity or activity of USP7 to stabilize viral proteins. Interacts with ATXN1 and the strength of interaction is influenced by the length of the poly-Gln region in ATXN1. A weaker interaction seen with mutants having longer poly-Gln regions.,tissue specificity:Widely expressed.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
組織表達： Expressed in neural progenitor cells (at protein level) (PubMed:21258371). Widely expressed. Overexpressed in prostate cancer.
其他名稱： Deubiquitinating enzyme 7;HAUSP;herpes virus associated;Herpes virus associated ubiquitin specific protease;Herpesvirus-associated ubiquitin-specific protease;TEF 1;tef-1;TEF1;Ubiquitin carboxyl terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin specific peptidase 7 (herpes virus associated);Ubiquitin specific peptidase 7;Ubiquitin specific peptidase 7 herpes virus associated;Ubiquitin specific processing protease 7;Ubiquitin specific protease 7 (herpes virus associated);Ubiquitin Specific Protease 7;Ubiquitin specific protease 7 herpes virus associated;Ubiquitin thioesterase 7;ubiquitin thiolesterase 7;Ubiquitin-specific-processing protease 7;UBP 7;UBP-7;UBP7;UBP7_HUMAN;USP 7;usp-7;USP7;VMW110-ASSOCIATED PROTEIN,135-KD.
實測條帶： 135kD
功能： catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,enzyme regulation:Inhibited by N-ethyl-maleimide (NEM) and divalent cations. Tolerates high concentrations of NaCl but is inhibited at concentrations of 195 mM and higher.,function:Cleaves ubiquitin fusion protein substrates. Deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis.,PTM:Polyneddylated.,PTM:Polyubiquitinated.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 MATH domain.,subcellular location:Present in a minority of ND10 nuclear bodies. Association with VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus.,subunit:Monomer. Interacts with TP53, MDM2 and UBXN6. Interacts with herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 and Epstein-Barr virus EBNA1. EBNA1 shows a 10-fold higher affinity than TP53 and can compete with it for USP7 binding. Binding to VMW110 may modulate the substrate specificity or activity of USP7 to stabilize viral proteins. Interacts with ATXN1 and the strength of interaction is influenced by the length of the poly-Gln region in ATXN1. A weaker interaction seen with mutants having longer poly-Gln regions.,tissue specificity:Widely expressed.,
相關產品： RS0001,RS0002,YM3028,YM3029
細胞定位： Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
組織表達： Expressed in neural progenitor cells (at protein level) (PubMed:21258371). Widely expressed. Overexpressed in prostate cancer.
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