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PP1C mouse mAb

商品貨號(hào)： PLA005216

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： ppp1cc
Human_gene_id： 5501
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5501
Human_swiss_prot_no： P36873
Human_swiss_link： http://www.uniprot.org/uniprotkb/P36873/entry
Mouse_swiss_prot_no： P63087
Mouse_swiss_link： http://www.uniprot.org/uniprot/P63087
特異性： This antibody detects endogenous levels of PP1C and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： wb 1:500
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： EC 3.1.3.16;PP 1G;PP-1G;PP1G;PP1G_HUMAN;PP1gamma;PPP 1G;PPP1CC;PPP1CC protein;PPP1G; Protein phosphatase 1 catalytic subunit gamma isoform;Protein phosphatase 1C catalytic subunit;Protein phosphatase 1C subunit;Protein phosphatase 2C gamma isoform; Serine/threonine phosphatase 1 gamma;Serine/threonine protein phosphatase PP1 gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit.
實(shí)測(cè)條帶： 38kD
信號(hào)通路： Oocyte meiosis;Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Regulates Actin and Cytoskeleton;Insulin_Receptor;
功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,miscellaneous:Microcystin toxin is bound to Cys-273 through a thioether bond.,online information:The things we forget -Issue 32 of March 2003,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subcellular location:Colocalizes with SPZ1 in the nucleus.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin; disulfide-linked. Interacts with PPP1R3B and PPP1R7. Isoform gamma-2 interacts with SPZ1 (By similarity). Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus. Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus speckle . Chromosome, centromere, kinetochore . Cleavage furrow . Midbody . Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center . Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430). Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430). Colocalizes with DYNLT4 in the microtubule organizing center (MTOC)(PubMed:23789093). .
組織表達(dá)： Embryonic kidney,Placenta,Skeletal muscle,
科研貨號(hào)： PLA005216

PP1C mouse mAb

Catalog No PLA005216

Product information

發(fā)貨日期： 7
基因名稱： ppp1cc
Human_gene_id： 5501
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5501
Human_swiss_prot_no： P36873
Human_swiss_link： http://www.uniprot.org/uniprotkb/P36873/entry
Mouse_swiss_prot_no： P63087
Mouse_swiss_link： http://www.uniprot.org/uniprot/P63087
特異性： This antibody detects endogenous levels of PP1C and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Monoclonal, Mouse
稀釋： wb 1:500
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： EC 3.1.3.16;PP 1G;PP-1G;PP1G;PP1G_HUMAN;PP1gamma;PPP 1G;PPP1CC;PPP1CC protein;PPP1G; Protein phosphatase 1 catalytic subunit gamma isoform;Protein phosphatase 1C catalytic subunit;Protein phosphatase 1C subunit;Protein phosphatase 2C gamma isoform; Serine/threonine phosphatase 1 gamma;Serine/threonine protein phosphatase PP1 gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit.
實(shí)測(cè)條帶： 38kD
信號(hào)通路： Oocyte meiosis;Vascular smooth muscle contraction;Focal adhesion;Long-term potentiation;Regulates Actin and Cytoskeleton;Insulin_Receptor;
功能： catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.,miscellaneous:Microcystin toxin is bound to Cys-273 through a thioether bond.,online information:The things we forget -Issue 32 of March 2003,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-1 subfamily.,subcellular location:Colocalizes with SPZ1 in the nucleus.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin; disulfide-linked. Interacts with PPP1R3B and PPP1R7. Isoform gamma-2 interacts with SPZ1 (By similarity). Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Cytoplasm . Nucleus. Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus speckle . Chromosome, centromere, kinetochore . Cleavage furrow . Midbody . Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center . Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430). Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430). Colocalizes with DYNLT4 in the microtubule organizing center (MTOC)(PubMed:23789093). .
組織表達(dá)： Embryonic kidney,Placenta,Skeletal muscle,
科研貨號(hào)： PLA005216

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