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Aurora Kinase A mouse mAb

商品貨號： PLA005229

適應(yīng) 性： 人,猴

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： aurka
Human_gene_id： 6790
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6790
Human_swiss_prot_no： O14965
Human_swiss_link： http://www.uniprot.org/uniprotkb/O14965/entry
Mouse_swiss_prot_no： P97477
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97477
特異性： This antibody detects endogenous levels of Aurora Kinase A and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： wb 1:500 icc 1:50. IF 1:50-200
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： AIK;ARK-1;ARK1;AURA;AURKA;Aurora 2;Aurora A;Aurora Family Kinase 1;aurora kinase A;Aurora Related Kinase 1;Aurora-related kinase 1;Aurora/IPL1 Like Kinase; Aurora/IPL1 Related Kinase 1;Aurora/IPL1-related kinase 1;AURORA2;AYK1;BRAK;Breast Tumor Amplified Kinase;Breast tumor-amplified kinase;BTAK;hARK1;IAK ;IPL1 Aurora Related Kinase 1;IPL1 Related Kinase;MGC34538;OTTHUMP00000031340;OTTHUMP00000031341;OTTHUMP00000031342;OTTHUMP00000031343;OTTHUMP00000031344; OTTHUMP00000031345;OTTHUMP00000166071;OTTHUMP00000166072;PPP1R47;Protein phosphatase 1, regulatory subunit 47;Serine/threonine kinase 15;Serine/threonine kinase 6;Serine/threonine kinase;Serine/threonine-protein kinase 15;Serine/threonine-protein kinase 6;Serine/threonine-protein kinase aurora-A;STK15;STK6; STK6_HUMAN;STK7.
實測條帶： 46kD
信號通路： Oocyte meiosis;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Although authors have considered STK6 and STK15 as two different proteins, it is clear that they are the same protein.,disease:Defects in AURKA are responsible for numerical centrosome aberrations including aneuploidy.,function:May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. May be involved in microtubule formation and/or stabilization. Phosphorylates ARHGEF2 and BORA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.,subunit:Interacts with TACC1 and CPEB1. Interacts with its substrates BORA and ARHGEF2.,tissue specificity:Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, neuron projection . Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). .
組織表達： Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
科研貨號： PLA005229

Aurora Kinase A mouse mAb

Catalog No PLA005229

Product information

發(fā)貨日期： 7
基因名稱： aurka
Human_gene_id： 6790
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6790
Human_swiss_prot_no： O14965
Human_swiss_link： http://www.uniprot.org/uniprotkb/O14965/entry
Mouse_swiss_prot_no： P97477
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97477
特異性： This antibody detects endogenous levels of Aurora Kinase A and does not cross-react with related proteins.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： wb 1:500 icc 1:50. IF 1:50-200
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： AIK;ARK-1;ARK1;AURA;AURKA;Aurora 2;Aurora A;Aurora Family Kinase 1;aurora kinase A;Aurora Related Kinase 1;Aurora-related kinase 1;Aurora/IPL1 Like Kinase; Aurora/IPL1 Related Kinase 1;Aurora/IPL1-related kinase 1;AURORA2;AYK1;BRAK;Breast Tumor Amplified Kinase;Breast tumor-amplified kinase;BTAK;hARK1;IAK ;IPL1 Aurora Related Kinase 1;IPL1 Related Kinase;MGC34538;OTTHUMP00000031340;OTTHUMP00000031341;OTTHUMP00000031342;OTTHUMP00000031343;OTTHUMP00000031344; OTTHUMP00000031345;OTTHUMP00000166071;OTTHUMP00000166072;PPP1R47;Protein phosphatase 1, regulatory subunit 47;Serine/threonine kinase 15;Serine/threonine kinase 6;Serine/threonine kinase;Serine/threonine-protein kinase 15;Serine/threonine-protein kinase 6;Serine/threonine-protein kinase aurora-A;STK15;STK6; STK6_HUMAN;STK7.
實測條帶： 46kD
信號通路： Oocyte meiosis;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Although authors have considered STK6 and STK15 as two different proteins, it is clear that they are the same protein.,disease:Defects in AURKA are responsible for numerical centrosome aberrations including aneuploidy.,function:May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. May be involved in microtubule formation and/or stabilization. Phosphorylates ARHGEF2 and BORA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.,subunit:Interacts with TACC1 and CPEB1. Interacts with its substrates BORA and ARHGEF2.,tissue specificity:Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, neuron projection . Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). .
組織表達： Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
科研貨號： PLA005229

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