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NPCL1 rabbit pAb

商品貨號： PLA021565

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： NPC1L1
蛋白名稱： Niemann-Pick C1-like protein 1
Human_gene_id： 29881
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29881
Human_swiss_prot_no： Q9UHC9
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UHC9/entry
Mouse_gene_id： 237636
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=237636
Mouse_swiss_prot_no： Q6T3U4
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q6T3U4/entry
Rat_gene_id： 432367
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=432367
Rat_swiss_prot_no： Q6T3U3
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q6T3U3/entry
特異性： This antibody detects endogenous levels of NPCL1 at Human, Mouse,Rat
組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000 IHC 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Niemann-Pick C1-like protein 1
分子量： 149kD
功能： Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. .
組織表達(dá)： Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
科研貨號： PLA021565

NPCL1 rabbit pAb

Catalog No PLA021565

Product information

基因名稱： NPC1L1
蛋白名稱： Niemann-Pick C1-like protein 1
Human_gene_id： 29881
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29881
Human_swiss_prot_no： Q9UHC9
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q9UHC9/entry
Mouse_gene_id： 237636
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=237636
Mouse_swiss_prot_no： Q6T3U4
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q6T3U4/entry
Rat_gene_id： 432367
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=432367
Rat_swiss_prot_no： Q6T3U3
Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q6T3U3/entry
特異性： This antibody detects endogenous levels of NPCL1 at Human, Mouse,Rat
組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000 IHC 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Niemann-Pick C1-like protein 1
分子量： 149kD
功能： Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. .
組織表達(dá)： Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
科研貨號： PLA021565

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