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FRS2 Rabbit mAb

商品貨號(hào)： PRM8719

適應(yīng) 性： 人,小鼠,大鼠

￥800元

規(guī)格：

50ul

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商品描述

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： FRS2
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 57kD
MW(Observed)： 80kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG, Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號(hào)： PT1008R
特異性： Endogenous
基因名稱： FRS2
蛋白名稱： Fibroblast growth factor receptor substrate 2
別名： FRS2;Fibroblast growth factor receptor substrate 2;FGFR substrate 2;FGFR-signaling adaptor SNT;Suc1-associated neurotrophic factor target 1;SNT-1
Organism-1： Human
基因ID-1： 10818
SwissProt-1： Q8WU20
Organism-2： Mouse
基因ID-2： 327826
SwissProt-2： Q8C180
背景： function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,
細(xì)胞定位： Endomembrane system. Cytoplasmic, membrane-bound.

FRS2 Rabbit mAb

Catalog No PRM8719

Product information

發(fā)貨日期：現(xiàn)貨
靶點(diǎn)-Target： FRS2
反應(yīng)性-Reactivity：人,小鼠,大鼠
應(yīng)用-Applications： WB,IF,IP,ELISA
MW(Calculated)： 57kD
MW(Observed)： 80kD
宿主物種-Host Species： Rabbit
同種型-Isotype： IgG, Kappa
偶聯(lián)-Conjugate： Unmodified
推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
純化工藝： Protein A
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號(hào)： PT1008R
特異性： Endogenous
基因名稱： FRS2
蛋白名稱： Fibroblast growth factor receptor substrate 2
別名： FRS2;Fibroblast growth factor receptor substrate 2;FGFR substrate 2;FGFR-signaling adaptor SNT;Suc1-associated neurotrophic factor target 1;SNT-1
Organism-1： Human
基因ID-1： 10818
SwissProt-1： Q8WU20
Organism-2： Mouse
基因ID-2： 327826
SwissProt-2： Q8C180
背景： function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,
細(xì)胞定位： Endomembrane system. Cytoplasmic, membrane-bound.

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